The NAD+ Problem

NAD+ is a coenzyme present in every living cell, essential for mitochondrial energy production, DNA repair, sirtuin activation, and immune function. By your fifties, cellular NAD+ may be 50% lower than in your twenties.

NR (Nicotinamide Riboside)

Bioavailability: Can increase blood NAD+ by 40-60%. Has the most extensive human clinical trial database and FDA GRAS status. Cost: 3,000-6,000 INR/month.

NMN (Nicotinamide Mononucleotide)

A January 2026 head-to-head trial found NR and NMN produced comparable NAD+ elevation at equal doses (1,000 mg daily). FDA confirmed dietary supplement status in September 2025. Cost: 4,000-10,000 INR/month.

IV NAD+

100% bioavailability into bloodstream but rapid clearance. Expensive ($200-500 per session, 15,000-40,000 INR), time-consuming (2-4 hours), with limited clinical trial evidence.

My Clinical Perspective

Start with foundations that reduce NAD+ depletion. NR and NMN are comparable at equivalent doses. IV NAD+ reserved for acute use cases. Always measure intracellular NAD+ levels before and after supplementation.

At Genoryx, we offer IV NAD+ infusions alongside personalised oral supplementation protocols, all guided by NAD+ testing. Book a consultation and determine the optimal NAD+ strategy for your biology.