Evidence · Strong & indicated
Fluid & Electrolyte Infusion
Intravenous fluids and electrolytes for dehydration a physician has confirmed, given at a controlled rate when drinking enough is not possible.
30 minutes
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IV Therapy & NAD+
NAD+ Infusion (500 mg)
The 500 mg NAD+ infusion is a higher dose, prescribed after a physician review and usually once a lower dose has been tolerated.
- Duration
- 2-3 hours per infusion
- Sessions
- Loading phase: 2-4 sessions over 2 weeks; maintenance: monthly or as prescribed
- Downtime
- None — mild fatigue possible for a few hours post-infusion
NAD+ Infusion: options
Overview
This page covers the 500 mg NAD+ infusion, our higher-dose protocol. It is prescribed only after a physician review, usually for patients who have already tolerated a lower dose. Twice the NAD+ at the same controlled rate means a longer session, so plan for the full infusion window. The team will slow the drip if flushing or nausea appear. A higher dose is not automatically better: human outcome data for any NAD+ dose are still limited, and your physician will explain why this dose is being suggested for you.
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell. It is central to cellular energy production and is used by enzymes involved in DNA repair (PARPs), circadian rhythm regulation and the sirtuin family of proteins. NAD+ appears to fall with age: in human skin samples, NAD+ levels were lower in older donors than in younger ones (Massudi H et al., PLoS One, 2012). Whether this decline is a cause or a consequence of ageing is still being studied.
The science needs honest framing. In animal studies, raising NAD+ levels has improved mitochondrial function and markers of healthspan. In humans, the picture is less clear. A small 2019 pilot study (Grant R et al., Frontiers in Aging Neuroscience) found that plasma NAD+ did not rise during the first two hours of a slow 6-hour infusion, because the body cleared it so quickly. How much infused NAD+ reaches tissues is still an open question.
Human trials of NAD+ infusion for longevity outcomes have not been completed. We do not have randomised controlled trials showing that NAD+ infusions extend human lifespan or healthspan. What we have is a plausible mechanism, animal evidence and early human pharmacology. We do not offer NAD+ as an anti-ageing treatment, and we make no claim about how it will make you feel.
At Genoryx, NAD+ infusions are given under physician supervision. The infusion runs slowly over 2-3 hours because a faster rate can cause temporary flushing, nausea or chest tightness. These effects settle when the rate is reduced, but they are uncomfortable. Our medical team monitors you throughout and adjusts the rate to your tolerance.
NAD+ infusion is physician-assessed and prescribed only where clinically indicated after screening. It is not a standalone therapy. If it is used at all, it sits inside a programme built on exercise, nutrition, sleep and biomarker tracking. Book a consultation with our longevity physician to discuss whether NAD+ therapy is appropriate for your goals and health status.
What the evidence says
Evidence · EmergingPlausible biology and early human data. We tell you what is and is not known. How we grade evidence
What it shows
NAD+ falls with age in human tissue and is central to energy metabolism and DNA repair. Raising it in animals improves several measures of ageing.
What it does not show
In the human pilot study, infused NAD+ did not raise blood NAD+ for the first two hours. No completed trial shows that IV NAD+ improves health outcomes, at either dose.
- 01Massudi H, et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. (opens in a new tab)
In skin samples from 49 people, NAD+ fell with age in both men and women.
- 02Grant R, et al. A pilot study investigating changes in the human plasma and urine NAD+ metabolome during a 6 hour intravenous infusion of NAD+. Front Aging Neurosci, 2019. (opens in a new tab)
Pilot study: plasma NAD+ did not rise for the first two hours of a slow infusion. Two authors list commercial NAD+ affiliations.
- 03Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol, 2021. (opens in a new tab)
Review: NAD+ declines with age, but whether restoring it is safe and beneficial in ageing humans is not yet known.
What it can and cannot do
What it can do
- Deliver NAD+, a coenzyme central to energy metabolism and DNA repair, slowly and under monitoring.
- Be adjusted to you. Flushing, nausea or chest tightness settle when the team slows the rate.
What it cannot do
- Raise blood NAD+ quickly. In the human pilot study it did not rise for the first two hours of the infusion.Source [2]
- Improve health outcomes on current evidence. No completed trial shows that, at either dose.Source [3]
- Slow ageing. It is not offered as an anti-ageing treatment.
Numbers in brackets point to the studies above. Medical review: a physician who did not write this page checks each line against the source it cites, and checks that nothing reads as a promised result. How we review
Who it's for
A good fit
- Adults with low energy, once a physician has checked for other causes
- Adults who want to try NAD+ under monitoring, knowing the outcome evidence is early
- Professionals who want NAD+ inside a wider plan of sleep, exercise and nutrition
- Patients in integrated longevity protocols
- Adults who want the evidence explained before deciding
Talk to us first
- Pregnancy or breastfeeding
- Active cancer (NAD+ may support rapidly dividing cells — discuss with oncologist)
- Severe cardiac conditions (physician assessment required)
The markers that decide eligibility
No blood test measures whether you need NAD+. These are the safety checks before your first infusion.
Before your first session
- Tell us if you are pregnant or breastfeeding, or have cancer or a heart condition.
- Kidney, liver and blood-count results are checked before your first infusion.
- Plan for the full infusion window; mild tiredness for a few hours afterwards is possible.
- Nothing is mixed until a physician has prescribed it for you; it is given only where clinically indicated.
- Time to allow: 2-3 hours per infusion.
Your physician confirms at screening whether this is right for you. If anything above applies, tell us when you book.
What happens on the day
- 01
Screening
History, current medicines and vitals are checked. Relevant blood work is reviewed before your first infusion.
- 02
Prescription
The physician confirms the formulation and rate. Nothing is mixed until it is prescribed for you.
- 03
The infusion
A cannula is placed by our medical team and the infusion runs at a controlled rate: 2-3 hours per infusion.
- 04
Aftercare
Vitals are rechecked before you leave, and the next session is planned only if it is needed.
Equipment and method
- 01Clinical-grade NAD+ (nicotinamide adenine dinucleotide) IV formulation
- 02Controlled-rate infusion pump
- 03Physician monitoring throughout infusion
- 04Pre-infusion biomarker assessment
Physician oversight
Dr. Asritha, MD Anaesthesia, leads the execution of all IV therapy and HBOT protocols, ensuring clinical-grade safety, dosing accuracy, and emergency preparedness for every session.
Meet the clinical teamQuestions people ask
Who is the 500 mg dose for?
Patients who have tolerated a lower dose and whose physician sees a reason for a larger infusion, for example as part of a structured protocol with follow-up blood work. It is not offered as a first infusion.
Is 500 mg more effective than 250 mg?
Not necessarily. A larger dose raises blood NAD+ more, but there are no completed trials showing that it improves long-term health outcomes more than a smaller dose. That is why the choice is made by your physician and reviewed against how you respond.
What is NAD+ IV therapy, and what does the evidence show?
NAD+ is a coenzyme involved in cellular energy production, DNA repair and sirtuin activity, and its levels appear to fall with age. Human trials of health outcomes from NAD+ infusions have not been completed, so we make no claim about benefits. It is prescribed only where a physician finds a clinical reason after screening.
How much does NAD+ IV therapy cost in India?
NAD+ IV therapy pricing depends on the dose and protocol duration. We provide transparent pricing during your consultation. NAD+ is a premium therapy due to the clinical-grade formulation and physician-supervised administration required for safe delivery.
NAD+ IV vs NMN supplements — which is better?
NMN (nicotinamide mononucleotide) is an oral NAD+ precursor, and some oral precursors have been shown to raise blood NAD+ in human studies. IV NAD+ bypasses digestion, but a small 2019 pilot study found plasma NAD+ did not rise during the first two hours of a slow infusion, so how much reaches tissues is still unclear. Neither route has been shown to extend human healthspan. Your physician can advise which approach, if any, suits your goals.
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Your biological age is a number you can measure.
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