Diagnostics & Assessment
A DNA methylation blood test that estimates biological age and pace of ageing, interpreted by a physician alongside your blood work.
Your chronological age is the number of birthdays you have celebrated. Your biological age is the age your cells actually behave. These two numbers can diverge by decades — and biological age is the one that predicts your disease risk, functional decline, and life expectancy.
Epigenetic age testing measures biological age through DNA methylation analysis. Methylation is a chemical modification (the addition of a methyl group — CH3 — to cytosine bases in your DNA) that regulates gene expression without changing the underlying DNA sequence. As you age, methylation patterns shift in predictable ways across thousands of genomic sites. By measuring these patterns from a simple blood draw and running them through published algorithms, we can estimate your biological age. It is an estimate, with a margin of error, not an exact reading.
Three generations of epigenetic clocks exist, and understanding the differences matters. First-generation clocks (Horvath, 2013) were trained to predict chronological age from methylation, useful for proof of concept but limited in clinical utility. Second-generation clocks (GrimAge, 2019) were built using mortality-related data and predict risk of death and age-related disease better than calendar age alone. Third-generation tools (DunedinPACE, 2022) estimate the pace of aging, expressed as biological years per calendar year. A DunedinPACE of 1.0 means you age one biological year per calendar year. A score of 0.85 means you are aging slower than average. A score of 1.2 means faster than average.
Why this is useful: these markers can change. Early studies suggest that exercise, diet, sleep and stress management can shift them. The evidence is still small. In a 2021 pilot randomised trial of 43 healthy men aged 50 to 72 (Fitzgerald KN et al., Aging), an 8-week diet and lifestyle programme was associated with a Horvath clock age 3.23 years lower than in the control group. The study was small and short, used saliva samples, and the authors called for larger, longer trials. A lower clock score is not yet proof of longer or healthier life.
At Genoryx, we use epigenetic age as the "before and after" metric for your entire longevity program. Retest at 6-12 month intervals to objectively measure whether your interventions are working. Book a consultation with our longevity physician to begin your biological age assessment.
Plausible biology and early human data. We tell you what is and is not known. How we grade evidence
What it shows
DNA methylation clocks track age closely, and newer clocks predict disease and mortality better than age in years.
What it does not show
Results differ between clocks and labs, and no clock has yet been shown to guide a treatment that improves outcomes.
A clock built on 353 methylation sites predicted age accurately across 51 tissue and cell types.
PhenoAge predicted mortality, cancers and healthspan better than earlier clocks.
A pace-of-ageing measure that was reliable on retest and predicted disease, disability and mortality.
Numbers in brackets point to the studies above. Medical review: a physician who did not write this page checks each line against the source it cites, and checks that nothing reads as a promised result. How we review
A good fit
Talk to us first
Your physician confirms at screening whether this is right for you. If anything above applies, tell us when you book.
Before you arrive
Preparation instructions, such as fasting for blood work, are sent when you book.
The test
Consent and basic vitals, then the assessment itself: 15 minutes (blood draw) + 60-minute results consultation (2-3 weeks after draw).
Physician review
A Genoryx physician takes you through the results against your history and goals.
Your plan
A written summary with clear next steps and when to retest.
Every result is reviewed with you by a Genoryx physician, against your history and goals. Results are interpreted in context, not as a stand-alone diagnosis, and anything that needs specialist follow-up is referred on.
Meet the clinical teamA blood sample is drawn and sent to a specialized laboratory that analyzes DNA methylation patterns across hundreds of thousands of genomic sites. Validated algorithms (GrimAge, DunedinPACE) calculate your biological age and pace of aging. Results take 2-3 weeks and are reviewed in a detailed physician consultation.
Epigenetic age markers can change, and early studies suggest exercise, diet, sleep and stress management can shift them. In a small 2021 pilot trial of 43 men, an 8-week lifestyle programme was associated with a Horvath clock age 3.23 years lower than controls. Larger, longer trials are needed, and a lower score is not yet proof of longer life.
GrimAge tells you your biological age — a snapshot of cumulative aging damage. DunedinPACE tells you your pace of aging — how fast you are aging right now. Both are valuable: GrimAge shows where you stand, DunedinPACE shows the trajectory. Together, they provide the most complete picture of your aging biology.
Consumer DNA tests analyze genetic variants (SNPs) you were born with — your inherited risk. Epigenetic age testing measures DNA methylation — how your genes are currently being expressed. Genetics is your hardware; epigenetics is the software running on it. Epigenetic age changes with lifestyle, which is precisely why it is useful as a longevity metric.
Evidence · Established
The fasting blood panel in the 400+ parameter entry assessment: heart, metabolic, hormone, liver, kidney and inflammatory health, read with a physician.
30-45 minutes (blood draw) + 60-minute physician consultation
Evidence · Strong & indicated
A 60-second bioelectrical impedance scan of muscle, fat, visceral fat and body water by body segment, reviewed with a physician.
60 seconds (scan) + 15-minute physician review
Evidence · Established
Dual-energy X-ray absorptiometry, a reference method for measuring fat, lean mass, visceral fat and bone density region by region.
10-15 minutes (scan) + 30-minute physician review
Start with the 400+ parameter entry assessment and a 60-minute physician consultation at either Hyderabad clinic. Open seven days, 11 AM to 9 PM.
Book a consultation