Oestradiol Estradiol (E2)
The main female hormone, made for the most part in the ovaries.
Also printed asEstradiol · E2 · Serum Estradiol · 17-beta Estradiol
What it measures
The main female sex hormone, which swings widely across the menstrual cycle.
Runs the cycle, protects bone density and affects mood and skin; the cycle day decides whether a number is normal.
Why it matters for how long you stay well
It protects bone, blood vessels and mood, and the fall around menopause is why bone loss speeds up then, which makes the years either side of it the ones worth planning for.
How it shows up in daily life
In women it swings right through the monthly cycle, so the day the sample was taken changes what the number means.
High and low readings
When it reads high
Depends entirely on cycle day.
When it reads low
Low around menopause, or with heavy training and low body fat.
What moves it
Daily life
- where you are in your cycle
- body fat, which raises it
- alcohol
- very low body weight or very hard training, which lower it
Medicines known to shift it
- oral contraceptives (lower it)
Listed so a result can be read in context. It is not advice to start, stop or change any medicine; that decision belongs with your physician.
Common questions
What does Estradiol (E2) measure?
The main female sex hormone, which swings widely across the menstrual cycle. Runs the cycle, protects bone density and affects mood and skin; the cycle day decides whether a number is normal.
What does a high Oestradiol result usually mean?
Depends entirely on cycle day.
What does a low Oestradiol result usually mean?
Low around menopause, or with heavy training and low body fat.
What is the usual reference range for Oestradiol?
A broad adult reference band is 15–350 pg/mL. Labs differ, so read your result against the band printed on your own report.
Educational only, not a diagnosis. A single number means little without your history and the rest of your panel, so discuss your own results with your physician.
Typical adult reference band
- Adults
- 15–350 pg/mL
Labs differ. The band printed on your own report is the one that applies to your result.
Reported in pg/mL
Ageing relevance
3/5
A moderate ageing association; used in clinical longevity panels.
Worth knowing
In men it is made by converting testosterone, which is why carrying more body fat raises it.
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