Knowledge Hub
Dr. R. Brahmananda Reddy
6 April 2026

NAD+ (nicotinamide adenine dinucleotide) is not a vitamin, a supplement, or a drug. It is a coenzyme present in every living cell, essential for converting food into energy, repairing damaged DNA, activating sirtuins (the longevity genes), and maintaining cellular communication.
The problem: NAD+ levels decline with age. Research published in Cell Metabolism shows that by age 60, most people have roughly half the NAD+ they had at 20. This decline contributes to mitochondrial dysfunction, impaired DNA repair, chronic inflammation, and metabolic slowdown — the hallmarks of aging at the cellular level.
Oral NAD+ precursors (NMN, NR) have gained popularity, but bioavailability is limited by the digestive system. IV NAD+ bypasses the gut entirely, delivering the molecule directly into the bloodstream at 100% bioavailability. A typical session delivers 250-500mg over 2-4 hours.
The animal evidence is compelling: NAD+ restoration extends lifespan in mice, improves mitochondrial function, and reverses age-related tissue damage. Human evidence is still emerging — clinical trials are showing improvements in muscle function, cognitive performance, and inflammatory markers, but long-term longevity data in humans is not yet available.
We believe in honest evidence framing: NAD+ is one of the most promising molecules in longevity science, backed by strong mechanistic data and encouraging early human results. It is not a miracle cure, and we never position it as one.
Our longevity physician can assess whether NAD+ therapy is appropriate based on your biomarker profile, health goals, and current health status. Book a consultation to discuss your options.
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UK-trained physician and founder of Genoryx. Writes about longevity medicine, healthspan optimization, and evidence-based wellness.

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