Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell, serving as the central molecule in cellular energy production and a critical substrate for enzymes involved in DNA repair (PARPs), circadian rhythm regulation, and the sirtuin family of longevity-associated proteins. NAD+ levels decline approximately 50% between the ages of 40 and 60, and this decline is increasingly understood as both a consequence and a driver of biological aging. The science is compelling but requires honest framing. Animal studies have consistently demonstrated that restoring NAD+ levels extends healthspan, improves mitochondrial function, enhances DNA repair capacity, and activates sirtuins — a family of proteins that regulate cellular stress resistance, inflammation, and metabolism. A 2024 study published in Nature confirmed that intravenous NAD+ supplementation does significantly increase blood NAD+ levels in humans — resolving a key question about bioavailability that had been debated for years. However — and this is where intellectual honesty matters — human longevity trials are still in progress. The animal data is exciting and biologically plausible, but we do not yet have completed randomized controlled trials demonstrating that NAD+ infusions extend human lifespan. What we do have is strong mechanistic rationale, robust animal evidence, confirmed bioavailability in humans, and a growing body of clinical observations suggesting improvements in energy, cognitive clarity, and recovery. At Genoryx, we offer NAD+ infusions at clinically meaningful doses under physician supervision. The infusion is administered slowly over 2-3 hours because rapid infusion can cause temporary flushing, nausea, or chest tightness — side effects that are harmless but uncomfortable. Our medical team monitors you throughout and adjusts the infusion rate to your tolerance. NAD+ infusion is not a standalone therapy — it is most effective as part of an integrated longevity protocol alongside exercise, nutrition, sleep optimization, and biomarker tracking. Book a consultation with our longevity physician to determine if NAD+ therapy is appropriate for your goals and health status.