Knowledge Hub
Dr. R. Brahmananda Reddy
7 April 2026

Hair is one of the most metabolically active tissues in the body. When something is wrong systemically — a hormonal imbalance, nutrient deficiency, or metabolic dysfunction — hair is often the first tissue to show it.
DHT binds to androgen receptors with double the affinity of testosterone and a dissociation rate five times slower. The difference between hair loss and hair retention is androgen receptor sensitivity, not DHT levels.
Both hypothyroidism and hyperthyroidism cause diffuse hair loss. Subclinical thyroid dysfunction (TSH 3.5-4.5) can cause hair thinning long before formal diagnosis.
In women, insulin resistance stimulates ovarian androgen production. In men, it increases 5-alpha-reductase activity and promotes scalp inflammation.
A 2025 study found associations between hair loss and reduced iron, ferritin, copper, selenium, vitamin D, and B12. Ferritin below 40 ng/mL is associated with increased shedding.
Comprehensive hormonal panel (testosterone, DHT, thyroid, cortisol, insulin), nutrient assessment, inflammatory markers, and metabolic assessment — then treat root causes before topical solutions.
At Genoryx, we approach hair loss as a systemic health signal. Book a consultation and discover what your hair is telling you about your internal health.
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UK-trained physician and founder of Genoryx. Writes about longevity medicine, healthspan optimization, and evidence-based wellness.
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