The Protein Paradox

Protein generates genuine scientific debate in longevity circles: adequate protein is essential for muscle mass, bone density, and immune function, but protein activates mTOR, which when chronically elevated may accelerate aging.

Anabolic Resistance After 40

Skeletal muscle cells become less responsive to the anabolic signal from protein intake. Older adults need more protein per meal to achieve the same muscle-building effect.

The Leucine Threshold

Adults over 40 need 2.5-3.0 grams of leucine per meal (about 30-45 grams of protein). Leucine acts as the ignition key for muscle protein synthesis.

The mTOR Debate

mTORC1 promotes growth but suppresses autophagy. However, after 40, the consequences of sarcopenia are a far greater and more immediate threat than theoretical mTOR-driven aging.

The Practical Resolution

Daily total: 1.2-1.6 g/kg body weight. Distribute across 2-3 meals crossing the leucine threshold. Front-load protein toward earlier meals. Incorporate periodic fasting for autophagy.

The Indian Diet Challenge

Average protein intake in India is 0.6-0.8 g/kg — below even the conservative RDA. Practical adjustments: add paneer, eggs, whey protein, and increase dal portions.

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At Genoryx, we assess body composition via DEXA scan and design personalised nutrition protocols. Book a consultation and protect the muscle mass that determines your quality of life after 40.