Question 1

Is testosterone replacement therapy safe long-term?

Accepted Answer

When prescribed for diagnosed hypogonadism and monitored properly, TRT has a well-established safety profile. The key risks — polycythemia, potential prostate concerns, and fertility suppression — are managed through regular blood work and clinical oversight. Large-scale studies, including the TRAVERSE trial (2023), found no increased cardiovascular risk in men appropriately treated for hypogonadism. Improper use without monitoring is where risks escalate.

Question 2

Will TRT affect my fertility?

Accepted Answer

Yes. Exogenous testosterone suppresses the HPG axis, reducing LH and FSH, which in turn reduces sperm production — sometimes to zero. If fertility is a current or future goal, discuss this with your physician before starting. Options include HCG co-administration to maintain testicular function, or deferring TRT until family planning is complete.

Question 3

How soon will I notice results?

Accepted Answer

Improvements in energy, mood, and libido typically begin within 3-6 weeks. Body composition changes (increased lean mass, reduced fat) become noticeable at 3-6 months. Bone density improvements take 12 months or longer. We set realistic timelines during your initial consultation — TRT is not an overnight fix, but a sustained optimisation.

Evidence-based longevity protocols.

Evidence-based longevity protocols.

Testosterone Optimization (TRT)

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